Gabapentin (preanesthesia, potentially postanesthesia) Fearful/anxious or fractious cats may benefit from receiving gabapentin, an anxiolytic, prior to travel to the clinic.7 Although the efficacy of gabapentin for acute pain relief is undetermined, decreased anxiety alleviates the intensity of pain in humans,8 and this same anxiety–pain relationship is thought to apply to cats because of the commonality of human and animal pain/fear/anxiety pathways. There are several case reports and one study involving use of gabapentin for control of acute pain in cats.9 Gabapentin may be more effective in patients with chronic, particularly neuropathic, pain.Patients undergoing anesthesia for treatment of chronic pain conditions and/or patients with pre-existing chronic pain undergoing anesthesia for other conditions could potentially benefit from gabapentin. 2.Opioid/α2 Agonist Combination (preanesthesia, commonly postanesthesia) Using opioids in combination with α2 agonists can provide analgesia of greater intensity and/or longer duration, generally allowing a lower dose of each drug class.11 Opioids commonly used in cats include morphine, methadone, hydromorphone, fentanyl, and buprenorphine. Butorphanol is an effective sedative in most cats, but the duration of analgesia is extremely short (≈90 minutes)12 and, as with most opioids, is variable among individual patients.5,12-14 A feline-specific, FDA-approved formulation of buprenorphine provides 24 hours of analgesia with a single SC injection.15 Although opioids are not needed in every procedure, it is the opinion of the author and pain experts that opioids should be used for surgical pain, especially if pain is expected to be moderate to severe.1-6 If opioids are not available, multimodal analgesic options should be emphasized and the α2 agonist dose can be increased (using the high end of the dose range). Opioid-mediated hyperthermia can occur in cats and is most often related to hydromorphone.4,5 α2 agonists (eg, medetomidine, dexmedetomidine) are classified as sedative-analgesic drugs, and dexmedetomidine is FDA-approved for use in cats.16 The reversible effects of α2 agonists can provide benefits of both safety and convenience. Because α2 agonists are effectively administered IM, cats can be sedated without the undue stress of restraint that is often necessary for IV injection. Although α2 agonists should not be administered to most cats with clinical cardiac disease, α2-mediated bradycardia may be beneficial in some cats with left ventricular outflow obstruction.17 Other comorbidities may need to be considered but are not necessarily contraindications. More information is available for the clinical use of α2 agonists in cats with comorbidities (see Suggested Reading). If α2 agonists are not available, the high end of the opioid dose should be considered and other sedatives added, if needed. 3.Local Anesthetic Blocks (intra-anesthesia, effects last into postanesthesia) Local/regional anesthesia should be considered as part of a multimodal protocol for pain relief after every surgery and traumatic injury.1-5,18,19 Local anesthetic drugs block pain transmission to the CNS, making them highly effective analgesics.18 Most of these drugs are inexpensive and most blocks are relatively easy to administer.1-5,18,19 In most patients, local anesthetic blockade provides profound pain relief (block-, drug-, and procedure-specific) both during the procedure and into recovery, beyond the drug’s expected duration of action.20-22 This is an important mechanism because it can be complicated to treat pain during recovery in some patients due to limited options and potential drug contraindications with specific diseases (eg, NSAIDs in most patients with renal disease). Local/regional blockade also decreases surgery-related chronic pain development in humans,23 and due to the commonality of the mammalian pain pathway, this effect is predicted to occur in cats. Lidocaine, bupivacaine, and ropivacaine are commonly used local anesthetics in cats 4.Ketamine Infusion (intra-anesthesia, potentially pre- and/or postanesthesia) Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that has a well-documented role in both acute34 and chronic35 pain control in humans through prevention and treatment of central sensitization, which is an amplification of the pain stimulus primarily due to activation of the normally inactive NMDA receptors. Ketamine is administered at a subanesthetic dose to directly antagonize NMDA receptors. This is a unique mechanism of action as compared with other analgesic drugs. Research in veterinary patients is limited but promising.9 Ketamine infusions are commonly administered to cats, easy to make/administer, and inexpensive.1-5,9,10 Adverse effects with the subanesthetic infusion dose are uncommon, even in patients that have comorbidities 5.NSAIDs (postanesthesia, potentially preanesthesia) The main source of surgical pain is inflammation; thus, NSAIDs are a crucial component of effective analgesia. NSAID administration can be initiated pre- instead of postanesthesia, depending on the likelihood the patient will develop hypotension or hypovolemia during surgery.