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Matt Brunke, DVM, CCRP, CVPP, CVA Diplomate, American College of Veterinary Sports Medicine and Rehabilitation

NUTRITIONAL SUPPLEMENTS FOR ANIMAL ATHLETES, WHAT KEEPS JOINT HAPPY?:
PART THREE

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Green Lipped Mussel
- New Zealand shellfish
- Perna canaliculus
- Studies in dogs suggest benefit, but results not consistent
- Omega-3?
- Minerals
- Vitamins C and E
- Chondroitin?

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Green Lipped Mussel
- Found in the waters around Australia and New Zealand
- Contains n-3 fatty acids
- EPA
- DHA
- ETA
- Contain about 15% GAG’s (chondroitin sulfate)
- Glycoproteins
- Freeze dried processing to retain its pharmacologic properties.

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Green Lipped Mussel (Perna spp)
- Studies - using subjective measures, RCCT
- Score reduction
- Pain
- Crepitus
- Joint Swelling
- Average intake in food - 77 mg/kg BW
- Third Study - RCCT
- 25 mg/kg intake showed no difference - blinded study

Bierer TL, Bui LM. J.Nutr 2002. Bui LM, Bierer TL. Vet Ther 2003

Dobenaker B, J Nutr, 2006

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RCCT Green Lipped Mussel
- Dogs with Clinical OA
- GLM vs. Carpofen vs. Placebo (n = 15 per group)
- No NSAIDS or steroids - 30 days before
- Carprofen 2 mg/kg
- Lyproflex (500 mg capsules)
- Initial dose 2000 mg 40 kg; 3000 mg over 40 kg; 10 days
- Half this dose - day 10
- Assessment Subjective and Force Plate at 4,8,12 weeks
- Owner and veterinary
- NSAIDs for rescue recorded
- Difference between GLM and placebo

Hielm-Bjorkman A et al, Evid. Based Alt. Comp.Med, 2007

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Eggshell Membrane (ESM)
- What is it?
- Thin membrane between raw eggshell and membrane
- Protein rich
- Naturally rich in elastin, collagen, glycosaminoglycans (gags)

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Boswellia serrata extract
- Frankincense - tree bark from India
- Mix of boswellia acids
- KBA, AKBA
- Anti-inflammatory effect (NSAID?)
- Anti- LOX
- Benefits seen in human DJD patients
- A study in dogs showed improved clinical signs - lameness, pain, stiff gait

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Boswellia Study in Dogs
- Unblinded open label study
- Subjective measures based on scoring systems in Austrian canine population.
- No other meds for 3-6 weeks. Confirmed radiographs and visual lameness
- 29 dogs; 24 completed
- Dose 400 mg per 10 kg/BW
- Assessed 2,4 and 6 weeks.
- 71% positive response
- No placebo

Reichling J. et al, Schweiz Arch Tiereheik, 2004

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Curcumin extract
- Active part of turmeric
- Antioxidant and anti-inflammatory effects
- One study in dogs showed improvement in clinical score by veterinarians
- Standard extracts are not well absorbed, but special ones are
- Got turmeric? It won’t provide equivalent effects
- But will stain everything yellow!

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Elk (or deer) Velvet
- Traditional Chinese Medicine modality
- From antler in fast growing stage (when its cartilage!)
- Farmed deer or elk
- Ethics??
- Active ingredient?
- Pilose antler peptide
- Omega-3’s and -6’s
- Chondroitin sulfate
- Minerals, amino acids, collagen

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Elk Velvet
- Quality Elk Velvet
- Inner core of elk antler at velvet stage
- Contains CS and collagen
- Pilose antler peptide
- Study Design
- Dogs more than 20 kg
- 1 or more affected joint
- No concurrent supplements or NSAIDS
- Owner and Veterinary Assessments
- Force plate analysis
- Day 0 - 30 on placebo
- Day 60 - 30-60 on QEVA
- 280 g of QEVA capsules start 20-40 kg one capsule

Moreau M et al, Can Vet J, 2004

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Cetyl-m
- Fatty acid from Swiss albino mice
- Mechanisms?
- Joint lubrication
- Decrease inflammation
- No studies in dogs

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Hyperimmune milk factor
- Natural component of milk - manage inflammation
- Cows immunized with intestinal bacterial antigens.
- High molecular weight IgG and antiinflammatory low molecular weight components.
- Concentrated version - MicroLactin - active ingredient in Duralactin.
- May reduce inflammation by blocking entry of neutrophil attachment to the endothelial wall

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HIMF
- Study of 8000 people with OA - 80% reported considerable improvement in joint pain and 72% reported less stiffness in morning.

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UC-2
Undenatured Type 2 Collagen
- Active immune modulator
- Reduces secretion of enzymes thatbreak down collagen
- Slows the inflammatory response
- 10mg SID per patient

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UC-2 - Research

Efficacy and Safety of Glycosylated Undenatured type-II Collagen (UC-II) in Therapy of Arthritic Dogs

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UC-2 - Research

Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination With Glucosamine and Chondroitin in Arthritis Dongs

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UC-2 - Research

Therapeutic Efficacy of Undenatured type-II Collagen (UC-II) in Comparison to Glucosamine and Chondroitin in Arthritic Horses

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UC-2 - Research

Evolution of the Effects of Undenatured Type-II Collagen (UC-II) as Compared to Robenacoxib on the Mobility Impairment Induced by Osteoarthritis in Dogs

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Questions?
Matt Brunke, DVM, CCRP, CVPP, CVA,DACVSMR
DrMattBrunke@gmail.com
DrBrunke.Wordpress.com