Nutritional Supplements for Animal Athletes - What Keeps Joints Happy? Part 3
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              p.1 p.1 Matt Brunke, DVM, CCRP, CVPP, CVA Diplomate, American College of Veterinary Sports Medicine and Rehabilitation NUTRITIONAL SUPPLEMENTS FOR ANIMAL ATHLETES, WHAT KEEPS JOINT HAPPY?: 
 PART THREEp.1
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              p.2 p.2 Green Lipped Mussel 
 - New Zealand shellfish
 - Perna canaliculus
 - Studies in dogs suggest benefit, but results not consistent
 - Omega-3?
 - Minerals
 - Vitamins C and E
 - Chondroitin?p.2
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              p.3 p.3 Green Lipped Mussel 
 - Found in the waters around Australia and New Zealand
 - Contains n-3 fatty acids
 - EPA
 - DHA
 - ETA
 - Contain about 15% GAG’s (chondroitin sulfate)
 - Glycoproteins
 - Freeze dried processing to retain its pharmacologic properties.p.3
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              p.4 p.4 Green Lipped Mussel (Perna spp) 
 - Studies - using subjective measures, RCCT
 - Score reduction
 - Pain
 - Crepitus
 - Joint Swelling
 - Average intake in food - 77 mg/kg BW
 - Third Study - RCCT
 - 25 mg/kg intake showed no difference - blinded studyBierer TL, Bui LM. J.Nutr 2002. Bui LM, Bierer TL. Vet Ther 2003 Dobenaker B, J Nutr, 2006 p.4
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              p.5 p.5 RCCT Green Lipped Mussel 
 - Dogs with Clinical OA
 - GLM vs. Carpofen vs. Placebo (n = 15 per group)
 - No NSAIDS or steroids - 30 days before
 - Carprofen 2 mg/kg
 - Lyproflex (500 mg capsules)
 - Initial dose 2000 mg 40 kg; 3000 mg over 40 kg; 10 days
 - Half this dose - day 10
 - Assessment Subjective and Force Plate at 4,8,12 weeks
 - Owner and veterinary
 - NSAIDs for rescue recorded
 - Difference between GLM and placeboHielm-Bjorkman A et al, Evid. Based Alt. Comp.Med, 2007 p.5
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              p.7 p.7 Eggshell Membrane (ESM) 
 - What is it?
 - Thin membrane between raw eggshell and membrane
 - Protein rich
 - Naturally rich in elastin, collagen, glycosaminoglycans (gags)p.7
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              p.11 p.11 Boswellia serrata extract 
 - Frankincense - tree bark from India
 - Mix of boswellia acids
 - KBA, AKBA
 - Anti-inflammatory effect (NSAID?)
 - Anti- LOX
 - Benefits seen in human DJD patients
 - A study in dogs showed improved clinical signs - lameness, pain, stiff gaitp.11
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              p.12 p.12 Boswellia Study in Dogs 
 - Unblinded open label study
 - Subjective measures based on scoring systems in Austrian canine population.
 - No other meds for 3-6 weeks. Confirmed radiographs and visual lameness
 - 29 dogs; 24 completed
 - Dose 400 mg per 10 kg/BW
 - Assessed 2,4 and 6 weeks.
 - 71% positive response
 - No placeboReichling J. et al, Schweiz Arch Tiereheik, 2004 p.12
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              p.15 p.15 Curcumin extract 
 - Active part of turmeric
 - Antioxidant and anti-inflammatory effects
 - One study in dogs showed improvement in clinical score by veterinarians
 - Standard extracts are not well absorbed, but special ones are
 - Got turmeric? It won’t provide equivalent effects
 - But will stain everything yellow!p.15
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              p.16 p.16 Elk (or deer) Velvet 
 - Traditional Chinese Medicine modality
 - From antler in fast growing stage (when its cartilage!)
 - Farmed deer or elk
 - Ethics??
 - Active ingredient?
 - Pilose antler peptide
 - Omega-3’s and -6’s
 - Chondroitin sulfate
 - Minerals, amino acids, collagenp.16
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              p.17 p.17 Elk Velvet 
 - Quality Elk Velvet
 - Inner core of elk antler at velvet stage
 - Contains CS and collagen
 - Pilose antler peptide
 - Study Design
 - Dogs more than 20 kg
 - 1 or more affected joint
 - No concurrent supplements or NSAIDS
 - Owner and Veterinary Assessments
 - Force plate analysis
 - Day 0 - 30 on placebo
 - Day 60 - 30-60 on QEVA
 - 280 g of QEVA capsules start 20-40 kg one capsuleMoreau M et al, Can Vet J, 2004 p.17
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              p.19 p.19 Cetyl-m 
 - Fatty acid from Swiss albino mice
 - Mechanisms?
 - Joint lubrication
 - Decrease inflammation
 - No studies in dogsp.19
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              p.20 p.20 Hyperimmune milk factor 
 - Natural component of milk - manage inflammation
 - Cows immunized with intestinal bacterial antigens.
 - High molecular weight IgG and antiinflammatory low molecular weight components.
 - Concentrated version - MicroLactin - active ingredient in Duralactin.
 - May reduce inflammation by blocking entry of neutrophil attachment to the endothelial wallp.20
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              p.21 p.21 HIMF 
 - Study of 8000 people with OA - 80% reported considerable improvement in joint pain and 72% reported less stiffness in morning.p.21
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              p.23 p.23 UC-2 
 Undenatured Type 2 Collagen
 - Active immune modulator
 - Reduces secretion of enzymes thatbreak down collagen
 - Slows the inflammatory response
 - 10mg SID per patientp.23
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              p.24 p.24 UC-2 - Research Efficacy and Safety of Glycosylated Undenatured type-II Collagen (UC-II) in Therapy of Arthritic Dogs p.24
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              p.25 p.25 UC-2 - Research Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination With Glucosamine and Chondroitin in Arthritis Dongs p.25
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              p.26 p.26 UC-2 - Research Therapeutic Efficacy of Undenatured type-II Collagen (UC-II) in Comparison to Glucosamine and Chondroitin in Arthritic Horses p.26
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              p.27 p.27 UC-2 - Research Evolution of the Effects of Undenatured Type-II Collagen (UC-II) as Compared to Robenacoxib on the Mobility Impairment Induced by Osteoarthritis in Dogs p.27
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              p.28 p.28 Questions? 
 Matt Brunke, DVM, CCRP, CVPP, CVA,DACVSMR
 DrMattBrunke@gmail.com
 DrBrunke.Wordpress.comp.28
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     00:15:31 00:15:31Nutritional Supplements for Animal Athletes - What Keeps Joints Happy? Part 5Matt Brunke, DVM, CCRP, CVPP, CVA, Diplomate, ACVSMRVetScope
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     00:20:23 00:20:23Nutritional Supplements for Animal Athletes - What Keeps Joints Happy? Part 2Matt Brunke, DVM, CCRP, CVPP, CVA, Diplomate, ACVSMRVetScope
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     00:20:45 00:20:45Nutritional Supplements for Animal Athletes - What Keeps Joints Happy? Part 1Matt Brunke, DVM, CCRP, CVPP, CVA, Diplomate, ACVSMRVetScope
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     00:17:32 00:17:32Nutritional Supplements for Animal Athletes - What Keeps Joints Happy? Part 4Matt Brunke, DVM, CCRP, CVPP, CVA, Diplomate, ACVSMRVetScope