What is feline calicivirus? Feline calicivirus is a virus that is an important cause of upper respiratory infections and oral disease in cats. This virus infects cats throughout the world and can cause disease in both domestic and exotic cat species. Although several different viruses and bacteria can cause respiratory disease in cats, calicivirus is one of the more common infectious agents isolated in cats with a respiratory infection. Information about some other infectious agents that can cause an upper respiratory infection in cats can be found in "Feline Upper Respiratory Infection". What are the clinical signs of a calicivirus infection?cat_open_mouth_ulcersfcv_2018_db2-01 The typical clinical signs of an upper respiratory infection involve the nose and throat such as sneezing, nasal congestion, conjunctivitis (inflammation of the membranes lining the eyelids), and discharge from the nose or eyes. The discharge may be clear or may become yellow/green in color. In addition to these typical symptoms, cats with a calicivirus infection often develop ulcers on the tongue, hard palate, gums, lips, or nose. These cats will usually salivate or drool excessively as the ulcers are very painful. Other non-specific signs of an upper respiratory infection include anorexia, lethargy, fever, enlarged lymph nodes, and squinting. Some strains of calicivirus may cause an infected cat to develop sudden painful lameness in one or more joints; this lameness occurs more frequently in kittens. Although rare, there is one specific strain of feline calicivirus that causes severe generalized disease. The initial symptoms involve the eyes, nose, and mouth, but the infected cat quickly develops a high fever, severe depression, edema of the legs and/or face, jaundice, and symptoms of multiple organ disease. This strain is highly infectious, and the death rate is reportedly up to 67%. How does a cat get a calicivirus infection? Calicivirus is highly contagious and infected cats can shed the virus in saliva or secretions from the nose or eyes. If an infected cat sneezes, airborne viral particles can be sprayed several meters through the air. It is speculated that the virus may also be shed in urine or feces, but this is not considered to be a major source of infection. The virus may survive for up to one week in a contaminated environment (and possibly longer in a cool, damp location). Susceptible cats can get an infection by direct contact with another infected cat or by environmental exposure to objects that have been contaminated with infectious secretions. People that have touched contaminated objects or an infected cat, can also spread the virus to susceptible cats. Although all susceptible cats may develop a calicivirus infection, symptoms tend to be more severe in young kittens. How long does a typical calicivirus infection last? Once a cat is exposed to calicivirus, it will go through an incubation period of 2-6 days before developing clinical signs which typically last for 14-21 days. During this entire time, the cat will potentially be infectious to other cats. At a minimum, infected cats will shed virus in their bodily secretions for 2-3 weeks. Following apparent recovery from the disease, as many as half of all infected cats may develop a carrier state in which they will continue to shed the virus. In some of these cats the carrier state may only last for a few months, but in a small percentage of cats the carrier state may persist for life. Carrier cats may or may not show any signs of infection when they are actively shedding calicivirus and serve as an important source of infection to susceptible cats. Female cats that are carriers of this virus can pass the infection on to their newborn kittens. How is a calicivirus infection diagnosed? In most cases, a presumptive diagnosis of a calicivirus infection is based on the characteristic clinical signs, especially if ulcers are present. A definitive diagnosis of the virus is not always necessary but may be recommended for breeding animals, or if an individual cat has an infection that is poorly responsive to treatment. Diagnosis may be confirmed by collecting samples of cells and discharges from the mouth, nose, or eyes and submitting these samples to a laboratory for specialized testing such as viral isolation, identification by a PCR (polymerase chain reaction) test or immune-histochemical staining. If the infection has spread to the lungs, samples may be collected for examination by a procedure called a transtracheal wash. If a cat is showing sudden signs of lameness, X-rays may be recommended to rule out other causes such as an injury. If a cat has persistent respiratory symptoms, your veterinarian will recommend additional diagnostic testing such as chest or skull X-rays, blood tests, or culture and sensitivity testing of abnormal discharges. How is a calicivirus infection treated? Most cats with an uncomplicated calicivirus infection can be treated symptomatically at home. Your veterinarian may prescribe an eye medication to be applied topically if your cat has a purulent (green/yellow) eye discharge. Although viral infections do not respond to antibacterial drugs, broad spectrum antibacterial drugs (e.g., amoxicillin-clavulanic acid combination, brand name Clavamox®) may be prescribed in an effort to prevent secondary bacterial infections from complicating the disease, particularly in kittens.Anti-inflammatory medication may be administered by your veterinarian (a one-time injection) to relieve symptoms of lameness. Cats that have persistent ulcers may benefit from treatments that support the immune system. Cats with nasal or airway congestion may benefit from increased environmental humidification, such as being taken into a steamy bathroom for 10-15 minutes several times per day (see handout “Techniques for Nebulization and Coupage in Cats” for further information). To minimize irritation from discharges, it is often helpful to wipe them away from the cat's face or eyes with a moist tissue. Since cats with a respiratory infection will have a decreased sense of smell, they often have a decreased appetite - feeding a slightly warmed, highly palatable canned food may help improve their appetite. In some cases, an appetite stimulant may be prescribed. If a cat is dehydrated, depressed, or has a severe case of illness, your veterinarian will recommend hospitalization for more intensive treatment, including intravenous fluids and other supportive treatments.