Principles of treatment of liver diseases 1) General care :- a) Give complete rest to patient b) Provide carbohydrate rich diet c) Provide salt and fat free diet d) Provide high quality protein diet 2) Specific treatment : - a) Identification of cause and use of specific therapy b) Antibiotics in bacterial and viral infections orally and parentrally e.g. Gentamicin @ 1-2mg /kg IM, IV, Ampicillin @ 5-10 mg /kg IM/IV orally. c) Antiprotozoan drugs in haemoprotozoan infectcion eg Berenil @ 5.5 - 7.0 mg /kg IM as 20% solution. a) Anthelmintics flukicides in parasitic infection e.g. Fenbendazole @ 5-10mg/ kg orally - Round worms Oxyclozanide @10mg/ kg orally- flukes b) Surgical intervention in case of bile duct obstruction due to bile stone and other reason. c) In case of poisoning specific with antidote should be used e.g. Chlorinated hydrocarbon arsenic lead poisoning 3) Supportive treatment a) Dextrose 25% solution @ 500-1000 ml for Large animal and 250 ml for dog IV b) Liver tonics eg inj Belamyl @ 5-10ml IM large animal Neohepatics @ 1- 2ml IM in small animal c) Vit.C,Vit A should be supplied d) Diuretics in ascites and edema e.g . Ridema @ 1-2mg 1kg IM/ IV e) Steroid to reduce inflammation and catabolism e.g .Dexona @ 0.04mg /kg IM f) Lipotrophic agents e.g .choline and methionine g) Calcium therapy in toxicities and to prevent guanidine intoxication e.g. calboral @ 100-300ml for large animal IV and 10 ml IV for dog as 10% solution. h) Mild purgatives / laxatives for evacuation of GI contents e.g. sweet oil @ 250-500ml orally.