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Initial Vaccination Protocol
Richard B. Ford, DVM, MS
North Carolina State University

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AAHA Canine Vaccination Guidelines

VACCINATION RECOMMENDATIONS Practice
RABIES VACCINATION (NEW)
OVERDUE for VACCINATION (NEW)
VACCINATION RECOMMENDATIONS Shelter-Housed Dogs
ANTIBODY TESTING vs VACCINATION (NEW)
VACCINE STORAGE & HANDLING (NEW)
LEGAL CONSIDERATIONS
THERAPEUTIC BIOLOGICS (NEW)
VACCINE ADVERSE REACTIONS
VACCINE TYPES
VACCINE STORAGE & HANDLING (NEW)
THERAPEUTIC BIOLOGICS (NEW)
LICENSING of VACCINES
FREQUENTLY ASKED QUESTIONS
REFERENCES and Appendices
LIFESTYLE FACTORS (NEW)

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Canine Vaccines
r Distemper B. bronchiseptica-AvL (intranasal)
Distemper-MLV B. bronchiseptica-killed (parenteral)
Measles B. bronchiseptica-AvL (oral)
Parvovirus-MLV Leptospirosis var. canicola
Parainfluenza Virus-MLV Leptospirosis var. icterohaemorr.
Adenovirus-2 (CAV-2)-MLV Leptospirosis var. pomona
Adenovirus-2 (CAV-2)-AvL Leptospirosis var. grippotyphosa
Adenovirus-2 (CAV-2)-killed r Lyme (OspA)
Rabies 1-year rcLyme (OspA + C)
Rabies 3-year Lyme (OspA)-killed
Coronavirus-MLV Lyme (OspA+C)-killed
Coronavirus-killed Crotalus atrox
Canine Influenza (H3N8)-killed Giardia
Canine Influenza (H3N2)-killed ...and others
Over 30 antigens ~ 120 vaccines

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Canine Vaccination Guidelines

INITIAL CORE SERIES
MLV or r Distemper
MLV Parvovirus
MLV Adenovirus-2
Rabies
3-dose series
Booster within 1 year

6 weeks
7 weeks
8 weeks
9 weeks
10 weeks
11 weeks
12 weeks
13 weeks
14 weeks
15 weeks
16 weeks

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Maternal Antibody Interference “window of susceptibility”

MLV Vaccines (distemper, parvovirus, adenovirus)
Recombinant Distemper (rCDV)
Titer
~50% ~15%
8 wk 12 wk 16 wk 18 to 20 wks

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Vaccination Recommendations During the COVID19 Pandemic

CDV-CPV-CAV2
- Pups between 6 and 20 weeks: 3 to 4 doses, 3-4 weeks apart.
Emphasis on the last 2 doses in the series.

- Adult, previously vaccinated > 20 weeks: booster dose can be delayed.

SEARCH: AAHA interim clinical considerations

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Feline Vaccination Guidelines

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Feline CORE Vaccines

INITIAL SERIES (Kitten)
MLV Panleukopenia
MLV Herpesvirus + Calicivirus

6 weeks
7 weeks
8 weeks
9 weeks
10 weeks
11 weeks
12 weeks
13 weeks
14 weeks
15 weeks
16 weeks

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Feline CORE Vaccines

INITIAL SERIES (Kitten)
MLV Panleukopenia
MLV Herpesvirus + Calicivirus
Recombinant Rabies (1 & 3 Year)

Killed = Adjuvant

Feline Leukemia (FeLV) is “Highly Recommended in Kittens”

6 weeks
7 weeks
8 weeks
9 weeks
10 weeks
11 weeks
12 weeks
13 weeks
14 weeks
15 weeks
16 weeks

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Feline Injection-Site Sarcoma

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Vaccination Recommendations During the COVID19 Pandemic

FVR-C-P
Kittens between 6 and 20 weeks: 3 to 4 doses, 3-4 weeks apart.
Emphasis on the last 2 doses in the series.

Adult, previously vaccinated > 20 weeks: booster dose can be delayed.

SEARCH: AAHA interim clinical considerations

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Why Vaccination FAILS to Immunize

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Breed Specific Parvovirus Vaccination Failure

Genetic “Non-Responder”

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VACCINE STORAGE & HANDLING

How long after reconstitution...?
1 hour

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Same Volume for ALL breeds?

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THANK YOU...